Ceftifur Hydrochloride(103980-44-5)
Whakaahuatanga Hua
Ko te Ceftiofur he paturopi o te momo cephalosporin (whakatupuranga tuatoru), kua raihanatia mo te whakamahi i nga rongoa kararehe.I whakaahuatia tuatahitia i te tau 1987.
He ātete ki te whākōkī ātete paturopi beta-lactamase, ā, he mahi ki ngā huakita Gram-positive me Gram-negative.E. coli riaka ātete ki te ceftiofur kua korerotia.
Ko te Ceftiofur Hydrochloride te momo tote hydrochloride o te ceftiofur, he semisynthetic, beta-lactamase-stable, whanui-spectrum, tuatoru-whakatupuranga cephalosporin me te mahi antibacterial.Ka herea e te Ceftiofur ki nga pūmua here penicillin-binding (PBPs) kei runga i te kiriuhi o roto o te pakitara o te pūtau huakita.Ko nga PBPs he enzymes e uru ana ki nga waahanga mutunga o te whakahiato i te pakitara o te pūtau huakita me te hanga ano i te pakitara pūtau i te wa e tipu ana me te wehenga.Ko te whakakore i nga PBPs ka pokanoa ki te hononga-whakawhitinga o nga mekameka peptidoglycan e tika ana mo te kaha me te pakari o te pakitara o te pakitara huakita.Ko te hua o tenei ka ngoikore te pakitara o te pūtau huakita me te lysis pūtau.
| NGA MEA | WHAKAMAHI | HUA | |
| Te ahua | Ma ki Off-white paura Crystalline | Whakaritea | |
| Tautuhinga | Te wa pupuri o te tihi matua i roto i te chromatogram i whiwhi me te otinga whakamatautau e rite ana ki tera o te tihi matua i roto i te chromatogram i whiwhi me te otinga tohutoro. | Whakaritea | |
| Tauhohenga o te Chloride | Whakaritea | ||
| Te ahua o te otinga | Maramatanga | Kaore i kaha ake i te Paerewa Turbidity No.1 | <1 |
| Tae | Kaua e pouri ake i te otinga paerewa Y9 | <8 | |
| Wairewa | Wairewa i roto i te N, N- Dimethylacetamide, paku wairewa ki te 5% o te konutai bicarbonate me te mewaro. | Whakaritea | |
| PH | 2.0~3.0 | 2.2 | |
| Ihirangi wai | 1.5%~4.0% | 1.6% | |
| Te hurihanga whatu motuhake | -115°~-127° | -117° | |
| Te whakarewa taumaha | NMT 0.0020% | Whakaritea | |
| Te toenga o te mura | NMT 0.20% | 0.15% | |
| Matū whai pānga | Ko te poke nui | NMT 0.20% | 0.09 |
| Ko nga poke katoa | NMT 1.50% | 0.38 | |
| Te toenga whakarewa | Ethyl Acetate | NMT 0.5000% | 0 |
| THF | NMT 0.0720% | 0.006 | |
| Acetone | NMT 0.5000% | 0.2739% | |
| Benzene | NMT 0.0002% | 0.0001 | |
| Te whakamatautau | Ceftifur Hydrochloride | NLT 98.0% | 100.4% |
| pūhaumāota | 6.0%~6.5% | 6.2% | |
| Endotoxin huakita | Iti iho i te 0.20EU/mg | Whakaritea | |
| Te whakawetiweti | Ka rite ki te whakamatautau | Whakaritea | |
| Te rahi o te matūriki | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| TE WHAKAMAHI | HE WHAKAMAHI I TE WHAKAMAHI KI TE WHAKAMAHI | ||
