Waikawa Tranexamic(1197-18-8)
Whakaahuatanga Hua
● Waikawa Tranexamic(1197-18-8)
● CAS No.:·1197-18-8
● EINECS Nama: 356.2222
● MF: C8H15NO2
● Mōkī: 25Kg/Drum
● Ko te waikawa tranexamic (TXA) he rongoa hei rongoa, hei aukati ranei i te mate nui o te toto mai i nga whara nui, te toto i muri i te whanautanga, te pokanga, te tango niho, te ihu, me te paheketanga taumaha.[2][3]Ka whakamahia hoki mo te angioedema tuku iho.[2][4]Ka tangohia ma te waha, ma te werohia ranei ki roto i te uaua.
Te tikanga mahi
Ko te waikawa tranexamic he tairitenga waihanga o te lysine waikawa amino.Ka mahi hei antifibrinolytic na roto i te herea whakamuri e wha ki te rima nga waahi whakawhiwhi lysine i runga i te plasminogen.Ma tenei ka whakaiti i te huringa o te plasminogen ki te plasmin, ka aukati i te paheketanga o te fibrin me te pupuri i te anga o te hanganga kopu o te fibrin. Ko te waikawa Tranexamic he waru nga wa te mahi antifibrinolytic o te analogue tawhito, te waikawa ε-aminocaproic. te mahi o te plasmin me te kaha ngoikore (IC50 = 87 mM), a ka taea e ia te aukati i te waahi kaha o te urokinase plasminogen activator (uPA) me te tino motuhake (Ki = 2 mM), tetahi o nga mea tino nui i roto i nga proteases serine katoa.
Nga mahi waikawa tranexamic
He maha nga wa ka whakamahia te waikawa tranexamic whai muri i nga raru nui.[13]Ka whakamahia te waikawa tranexamic ki te aukati me te rongoa i te mate toto i roto i nga momo ahuatanga, penei i nga tikanga niho, te whakaheke toto nui, me nga pokanga he nui te mate o te mate toto.
| Nga Tuemi Whakamatau | Paearu Pharmacopeial | Hua Whakamatau | |
| KAUPAPA | Te ahua: Ma, tata ma ranei, paura tioata | Te paura tioata ma | |
| Te wairewa: Ka memeha noa ki te wai me te waikawa ahetiki hukapapa, karekau e memeha ki te acetone me te waihano (96%) | Paahi | ||
| WHAKATAUTANGA | Ko te Arohanga Hinengaro Infrared: Kei te rite te tuāwhiorangi IR ki te waikawa Tranexamic CRS. | Paahi | |
| WHAKAMAHI | pH (2,2.3) | 7.0 〜8.0 | 7.4 |
| Nga Taonga Paanga (HPLC2.2.29) | poke A≤ 0.1 % | Kaore i kitea | |
| poke B≤ 0.2% | 0.03% | ||
| Nga pokeC Nga pokekore≤ 0.10% Nga poke D Ētahi atu poke | 0.002% 0.001% Kaore i kitea | ||
| Te tapeke o nga poke kore i tohua≤ 0.2% | 0.003% | ||
| Ko nga Halides e kiia ana hei Chlorides | ≤140ppm | <140ppm | |
| Ngaronga i te whakamaroke | ≤0.5% | 0.026% | |
| Te pungarehu whanariki | ≤0.1% | 0.027% | |
| WHAKAMAHI | Me noho i roto (i runga i te whakamaroke) 99.0% 〜101.0% | 100.1% | |
